Journal of General Virology

Fig. 3. A model for UNG function in the late phase of CMV DNA replication. The creation of viral DNA with uracil residues occurs by either misincorporation or cytosine deamination. Uracil residues are excised by UNG and AP sites are cleaved by AP endonuclease. The resulting nicks in the viral DNA can serve as initiation sites for rolling-circle replication and recombination-dependent replication. The double-stranded viral DNA is represented by two circular or linear black lines; single-stranded viral DNA is represented by single black lines. Newly synthesized DNA is indicated by a dashed line. Uracil residues in DNA are indicated by the letter 'U' alongside the black circular line. AP sites are indicated by gaps in the outer circle. The virus replication complex is indicated by the shaded, overlapping ovals. This figure was adapted from Courcelle et al. (2001).

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